MITRA Samaj has an approach of establishing a strategic alliance/partnership with local organizations/Civil Society Organizations (CBOs) across Nepal. This partnership connects the resources of partners and creates synergies in the program implementation. Local partners contribute their knowledge regarding the local context and utilize appropriate skills for implementing the program at a local level. Whereas MITRA Samaj provides technical assistance to these local partners for project/proposal design, networking and other capacity-building areas identified by partners.
MITRA Samaj has a strategic alliance with 72 NGOs/CBOs in 48 districts of Nepal.List of partners of MITRA Samaj
| SN | Districts | Name of Partner Organizations |
| 1 | Achham | Rural Oppressed Public Awareness Society |
| 2 | Achham | Participatory Rural Sustainable Development Center-Nepal |
| 3 | Argakhanchi | Kalika Development |
| 4 | Baglung | Dhaulagiri Community Resources Development Center |
| 5 | Bajhang | Group for Social and Technical Development Service |
| 6 | Baitadi | Mitra Sangh |
| 7 | Baitadi | Bhumeshwor Community Development Organization |
| 8 | Bajura | Participatory Effort Children Education & Women Initiative Nepal |
| 9 | Bajura | Good Governance Club District Coordination Committee |
| 10 | Banke | ENPROC Nepal |
| 11 | Banke | Environment and Child Rights Protection Center |
| 12 | Banke | UNESCO-Banke Club |
| 13 | Bara | Dalit Ethnic Upliftment center |
| 14 | Bardiya | Tharu Community Development Forum |
| 15 | Bardiya | Tharu Women Upliftment Centre |
| 16 | Chitwan | Campaign for Women Empowerment (CFWE) |
| 17 | Chitwan | Society for Health and Environment-SHE |
| 18 | Dadeldhura | Saipal Organization Development Society |
| 19 | Dailekh | Youth Manpower and Mobilization Center |
| 20 | Dang | Dang Plus |
| 21 | Dang | Nepal Woman Development Center |
| 22 | Dang | Nepal Red Cross Society (NRCS) |
| 23 | Darchula | Nepal Red Cross Society NRCS |
| 24 | Dhading | JagatJyoti Samudayik Bikas Samaj- |
| 25 | Dhanusha | Community Family Welfare Association |
| 26 | Dolpa | Information, Communication and Education Center |
| 27 | Doti | Center for Equal Access Development Nepal |
| Samaj Sewa | ||
| 28 | Gulmi | Gatisheel Janachetana Abhiyan |
| 29 | Humla | Nepal Astrya Partnership Organization |
| 30 | Jhapa | Ama Milan Kendra |
| 31 | Jhapa | Youth Awareness and Leadership Group |
| 32 | Jumla | Institute of Community Development |
| 33 | Kailali | Community Forum for Educational Development |
| 34 | Kailali | Forum for Awareness and Youth Activity (FAYA) Nepal |
| 35 | Kailali | Creation of Creative Society |
| 36 | Kailali | Rural Self Employment Service Center (RUSESC) |
| 37 | Kalikot | Chetana Bikash Kendra |
| 38 | Kalikot | Village Development and Save the Environment Forum |
| 39 | Kanchanpur | Samajik Samanta Abhiyan |
| 40 | Kanchanpur | Nepal Environment and Education Development Society |
| 41 | Kaski | Healthy Smile International |
| 42 | Kathmandu | Condom House Private Limited |
| 43 | Kathmandu | Nepal Beauticians Union |
| 44 | Kathmandu | Small Earth Nepal (SEN/Nepal) |
| 45 | Kathmandu | Women Waves Group, Kathmandu |
| 46 | Kavrepalanchowk | Community Improvement Forum (CIF-Nepal) |
| 47 | Lamjung | Rural Community Development Center (RCDC) |
| 48 | Mahottari | Women Culture Development Centre (WCDC) |
| 49 | Morang | Ama Milan Kendra, Morang |
| 50 | Mugu | Dalit Youth Community Development Center |
| 51 | Nawalparasi | Chautari Social Development Centre |
| 52 | Parsa | Sarbottam Yuba Club |
| 53 | Pyuthan | Kalika Bikash Kendra Nepal |
| 54 | Rautahat | Integrated Rural Development Centre |
| 55 | Rautahat | Integrated Sustainable Development Nepal |
| 56 | Rolpa | Rolpa Plus |
| 57 | Salyan | Dalit Development Society |
| 58 | Salyan | Nepal Red Cross Society NRCS Salyan |
| 59 | Saptari | Mount Everest Community Social Service Academy |
| 60 | Saptari | Development Concern Center |
| 61 | Sarlahi | CHETANA |
| 62 | Siraha | Samudaik Bikas Samiti |
| 63 | Siraha | Indreni Service Society |
| 64 | Sunsari | Mahila Sahayogi Samuha |
| 65 | Sunsari | Women and Children Awareness Centre |
| 66 | Surkhet | SAC Nepal |
| 67 | Surkhet | Deuti UNESCO Club |
| 68 | Surkhet | Social Awareness Center |
| 69 | Syangja | Andha Andhi Community Development Centre |
| 70 | Syangja | Suryodaya Youth Club |
| 71 | Tanahu | Seto Guransh Bal Bikash Sewa |
| 72 | Taplejung | Environment Conservation & Development Forum |
| 73 | Udayapur | Nawa Prabhat Sewa Pariwar |